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Director :

Hojatollah Rahimi. MD

Research Field of Interest :

  • Epidemiology researches for investigating the prevalence and ethiology of NAFLD
  • Basic research (pathophysiology, the mechanisms and genetics of NAFLD)
  • Clinical research (clinical spectrum, association with other diseases, diagnosis)
  • Treatment of NAFLD (treatment, prevention, nutritional intervention)


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Effect of Ramadan Fasting on Alanine Aminotransferase (ALT) in Non- Alcoholic Fatty Liver Disease (NAFLD)

Background: effect of Ramadan fasting on non-alcoholic fatty liver disease (NAFLD) is unknown, and limited studies have been conducted in this regard. Nutritional and behavioral changes in fasting individuals during Ramadan may affect NAFLD, including a high- fat and high- calorie diet, alterations of the body weight and sleep patterns, and insufficient physical activity. The present study aimed to evaluate the effects of these changes on alalie aminotransferase (ALT), an important indicator of NAFLD deterioration.

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Abnormal Liver Enzymes in Coal Tar Refinery Workers of Isfahan

Background: The effects of occupational exposure on liver function in oil refinery workers are not well known. In this study we evaluated the liver enzyme abnormalities among coal tar refinery workers.

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Flutamide-induced Hepatotoxicity: A Case Report

Background: Flutamide is a non-steroidal antiandrogen commonly used in the treatment of prostate cancer. Severe hepatotoxicity occurs in few patients, yet may be fatal. To date, none of the reported cases of flutamide hepatotoxicity has demonstrated thrombocytopenia and chronic liver disease. We report the case of a 55-year-old male with prostatic adenocarcinoma who developed liver failure after six months of flutamide therapy.

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Sonographic fatty liver in overweight and obese children, a cross sectional study in Isfahan

Background: Children’s obesity is a known health problem in the world and is a strong predictor of obesity in adulthood which increases the incidence of related diseases such as metabolic syndrome. According to the MONIKA project by the World Health Organization (WHO), Iran is one of the seven countries with a high rate of child obesity. Fatty liver is an abnormality related to metabolic syndrome, with higher prevalence in obese children according to some previous studies. This study investigates the presence of Sonographic Fatty Liver (SFL) in Iranian obese children in comparison with normal and overweight children.

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Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future

Background: Nonalcoholic steatohepatitis has become one of the most common liver-related health problems. This condition has been linked to an unhealthy diet and weight gain, but it can also be observed in nonobese people. The standard of care is represented by the lifestyle intervention. However, because this approach has several limitations, such as a lack of compliance, the use of many drugs has been proposed. The first-line pharmacological choices are vitamin E and pioglitazone, both showing a positive effect on transaminases, fat accumulation, and inflammation. 

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A 40 years old woman with monolobar Caroli’s syndrome treated by left hepatic lobectomy

Background: Caroli’s disease (CD) is a rare congenital abnormality characterized by dilatation of intra hepatic bile ducts, which causes stone formation, recurrent cholangitis and higher risk for biliary malignancy. Association of this anomaly with congenital hepatic fibrosis is named Caroli’s syndrome (CS). The monolobar involvement of CS is a very rare condition, curable by partial hepatectomy. We report a 40 year-old woman with recurrent epigastric pain without icterus with normal AST, ALT and alkaline phosphates for 5 years due to left lobe Caroli syndrome which was diagnosed by CT scan and MRCP.

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Research Projects

Effect of Ramadan fasting on alanine transferase (ALT) in nonalcoholic fatty liver disease (NAFLD)

PI: Hojatollah Rahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center


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