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METABOLIC DISORDER DEPARTMENT

Director :

Hojatollah Rahimi. MD

Research Field of Interest :

  • Epidemiology research for investigating the prevalence and etiology of NAFLD
  • Basic research (pathophysiology, the mechanisms and genetics of NAFLD)
  • Clinical research (clinical spectrum, association with other diseases, diagnosis)
  • Treatment of NAFLD (treatment, prevention, nutritional intervention)

Members

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Articles

Eugenol Administration Improves Liver Damage Induced by a Fructose‑Rich Diet

Background: The prevalence of metabolic syndrome (MetS) is increasing in developing countries that affects the liver in a variety of ways. This study was designed to investigate the protective role of eugenol on liver damage caused by fructose‑induced MetS.

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The Effect of Combined Training with Dietary Approaches to Stop Hypertension (DASH) on Liver Damage Indices in Patients with Non-Alcoholic Fatty Liver Disease

Background: Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition that is associated with sedentary lifestyle and inappropriate feeding habits. The main purpose of this study was to evaluate the effect of 12 weeks of combined training with dietary approaches to stop hypertension (DASH) diet on alanine transaminase (ALT) enzyme levels, liver fat, and anthropometric indices in patients with NAFLD.

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Effect of Ramadan Fasting on Alanine Aminotransferase (ALT) in Non- Alcoholic Fatty Liver Disease (NAFLD)

Background: effect of Ramadan fasting on non-alcoholic fatty liver disease (NAFLD) is unknown, and limited studies have been conducted in this regard. Nutritional and behavioral changes in fasting individuals during Ramadan may affect NAFLD, including a high- fat and high- calorie diet, alterations of the body weight and sleep patterns, and insufficient physical activity. The present study aimed to evaluate the effects of these changes on alalie aminotransferase (ALT), an important indicator of NAFLD deterioration.

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Abnormal Liver Enzymes in Coal Tar Refinery Workers of Isfahan

Background: The effects of occupational exposure on liver function in oil refinery workers are not well known. In this study we evaluated the liver enzyme abnormalities among coal tar refinery workers.

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Flutamide-induced Hepatotoxicity: A Case Report

Background: Flutamide is a non-steroidal antiandrogen commonly used in the treatment of prostate cancer. Severe hepatotoxicity occurs in few patients, yet may be fatal. To date, none of the reported cases of flutamide hepatotoxicity has demonstrated thrombocytopenia and chronic liver disease. We report the case of a 55-year-old male with prostatic adenocarcinoma who developed liver failure after six months of flutamide therapy.

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Sonographic fatty liver in overweight and obese children, a cross sectional study in Isfahan

Background: Children’s obesity is a known health problem in the world and is a strong predictor of obesity in adulthood which increases the incidence of related diseases such as metabolic syndrome. According to the MONIKA project by the World Health Organization (WHO), Iran is one of the seven countries with a high rate of child obesity. Fatty liver is an abnormality related to metabolic syndrome, with higher prevalence in obese children according to some previous studies. This study investigates the presence of Sonographic Fatty Liver (SFL) in Iranian obese children in comparison with normal and overweight children.

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A 40 years old woman with monolobar Caroli’s syndrome treated by left hepatic lobectomy

Background: Caroli’s disease (CD) is a rare congenital abnormality characterized by dilatation of intra hepatic bile ducts, which causes stone formation, recurrent cholangitis and higher risk for biliary malignancy. Association of this anomaly with congenital hepatic fibrosis is named Caroli’s syndrome (CS). The monolobar involvement of CS is a very rare condition, curable by partial hepatectomy. We report a 40 year-old woman with recurrent epigastric pain without icterus with normal AST, ALT and alkaline phosphates for 5 years due to left lobe Caroli syndrome which was diagnosed by CT scan and MRCP.

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Research Projects

Effect of Ramadan fasting on alanine transferase (ALT) in nonalcoholic fatty liver disease (NAFLD)

PI: Hojatollah Rahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center
 



The Effect of 12 Weeks Combined Training with DASH Diet on ALT Enzyme Level, Fatty Liver and Anthropomorphic Index in Patients with Non-Alcoholic Fatty Liver Disease

PI: Shila hassanian fard, MS, Sport Physiology
Colleagues: Khosro Jalai. PhD, Mohammad Hassan Emami. MD, Hojatollah Rahimi. MD, Nazila Tayari. MD



About uS

Digestive Diseases Research Center (DDRC) is an affiliated research center to Poursina Hakim Institute, a private organization for health promotion, patient care, research and education in biomedical sciences in the field of gastrointestinal diseases. Research activities have begun since 2000, just at the same time that Poursina Hakim Institute initiated its activity leading to establishment of Poursina Hakim Research Center in 2008. The institute including the research center was finally approved by the Iranian Ministry of Health and Medical Education as DDRC in 2015. Our research team is comprised of researchers in different fields including medicine, pharmacy, microbiology, pathology, statistics, etc. with the goal to translate research from bench- to-bedside benefiting mankind.

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info[at]pddrc.com
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